Paramedics say the TTC bus collided with a car at Kipling Avenue and Westhumber Boulevard at around 6 a.m. ET Sunday, then veered into a building.
The bus was travelling eastbound on Westhumber Boulevard when it collided with a Nissan Altima with three occupants inside. All three people in the car were taken to the trauma centre at Sunnybrook hospital.
After the collision, the bus continued through the intersection and hit the front of a CIBC building, Const. Clint Stibbe told CBC News.
It's not clear how many people were injured — one report says as many as six people on the bus suffered minor injuries.
Chirag Patel, who owns the Country Style doughnut shop in the same strip mall as the bank, witnessed the crash.
"I thought [the bus] was going it hit my store, it was going to hit me," he said. "It hit the CIBC bank, the front entrance and we called 911."
Patel went to the car's passenger side but was unable to open the door.
"I was in shock," he said.