Gunfire erupted inside Garden Restaurant at Chestnut and Dundas streets around 4 a.m., according to police.
A 32-year-old man was shot in the head and pronounced dead at the scene, according to paramedics.
The two female victims are both in their 20s, paramedics said. One of them was shot in the chest, the other in the abdomen. Their injuries are described as non-life-threatening.
Police are looking for two suspects.
Anyone with information is asked to contact police at 416-808-7400 x77387, Crime Stoppers anonymously at 416-222-TIPS (8477), online at www.222tips.com, text TOR and your message to CRIMES (274637), or Leave A Tip on Facebook.