The news conference starts at 10:30 a.m. ET Wednesday.
Ambrose and Moore are also expected to outline how the funds raised from the viral videos will be spent, and a new funding and research agreement with Brain Canada.
Ambrose was one of the many politicians across Canada who endured a bucket of icy cold water over their heads as part of an online campaign to raise awareness and research funds.
Other politicians — including Prime Minister Stephen Harper, who was nominated by actor Leonardo DiCaprio, among others — declined the cold shower but cut a cheque to the charity instead.
ALS, or amyotrophic lateral sclerosis, is often referred to as Lou Gehrig's disease, named after the late New York Yankees ballplayer. It's a progressive, neurodegenerative disease that affects the brain's nerve cells and the spinal cord.