The league made the announcement Thursday and said a makeup date has not yet been determined.
The decision comes while many communities south and east of downtown Buffalo have been blanked by a storm that has dumped 5 feet of snow since Monday. Another 1 to 3 feet was projected to fall by Friday.
Though downtown Buffalo, where the Sabres play, is mostly unaffected by the storm, there are numerous driving bans throughout the region which make it difficult for fans to get to the arena.
On Tuesday, an estimated crowd of 6,200 was able to attend Buffalo's 4-1 home win against San Jose.