Ford is in hospital undergoing a fourth round of chemotherapy and his brother Coun. Doug Ford told all-news TV station CP24 on Wednesday that another round will begin 21 days after the current treatment.
He also said that Rob Ford will "probably" need radiation and surgery after that, adding it's "really a long process."
During an appearance at city hall last week, the mayor said that his tumour hadn't shrunk, but it hadn't gotten larger either.
Doug Ford said he had a pretty good and "heart-felt conversation" with his brother at the hospital Tuesday night.
Doctors discovered the cancer in September and Rob Ford dropped his bid for re-election shortly afterwards, opting instead to run for city council.
He was elected by a wide margin.
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