The group left Mistissini, Que., north-east of Chibougamau, Que., 13 days ago.
Uranium extraction has been on the table in Mistissini since 2006.
A Boucherville-based company, Strateco Resources, has invested $120 million into developing a uranium mine in Mistissini in the last ten years.
“I want Quebecers to stand with us in this important, pivotal moment in our lives. We don't want our waters to be contaminated.” said Joshua Iserhoff, chair of the Cree Nation Youth Council.
Iserhoff says the Cree are not opposed to the development of natural resources, but says the risk uranium extraction could pose on the region’s watershed is too high.
The Mistissini project has been on hold for almost two years.
Now, the province is holding public hearings on uranium mining.
The outcome of those public hearings will determine whether Strateco will be allowed to continue the project.
Joshua Isherhoff spoke with CBC's Quebec A.M.