Oxford OPP and the Hickson fire department responded to the blaze, which they say was caused by the explosion, just before 6 a.m. on Tropicana Crescent in Sun Park Hidden Valley.
Investigators said two men and a woman were in the home at the time of the fire, but they were not hurt. No other buildings were damaged.
Police arrested one man and are holding him in custody. It's not immediately clear what he has been charged with.
The investigation is ongoing.