Her Royal Highness will spend Monday morning wrapping presents with students at the Northside Center in Harlem. The centre offers support and care for children working to overcome issues from poverty, to discrimination to mental health.
While the younger children, aged four and five, don't know what a Duchess is, they do know a princess is coming and are very excited, according to Thelma Dye, executive director of the centre. She notes it will be a long time before they appreciate the impact of this visit.
"When they look back on this when they're much older, it'll be very meaningful to them in terms of 'wow they understood, they cared, the world cares,'" she said.
While Kate remains in New York, Prince William will make a quick stop in Washington where he'll meet President Barack Obama and attend a World Bank conference. There the Duke will speak out against the illegal wildlife trade.
He returns to New York to attend an evening reception co-hosted by Hilary Clinton to highlight his conservation work.
The couple will reunite in the evening to attend a basketball game in Brooklyn. While officials won't confirm it, there is buzz that Will and Kate will meet hip hop's royal couple Jay-Z and Beyonce. With the Cleveland Cavaliers in town, they'll also meet NBA royalty in "King" Lebron James.
Hundreds braved cold weather to watch the Royal couple arrive on Sunday night at the Carlyle Hotel, the same hotel where Princess Diana stayed during her visit to New York in the 1980s. Colleen Green drove three days from Idaho so she and her daughter could see Will and Kate.
"To me it's just a historical moment," she said. "The chance to see Royalty live is just too good a chance to pass up."
Tuesday's schedule has the Duke and Duchess touring the National September 11 Memorial Museum. The trip ends with a star-studded gala at the Metropolitan Museum of Art at a fundraiser hosted by Tom Hanks. The money raised will go to the Duke and Duchess's alma mater St. Andrews University, where the two first met.