The boy, whose name has not been released, was taken to hospital where he later died.
A second teenager also sustained minor injuries in the attack.
Police said the two boys were assaulted on 18th Avenue by a group of other teens at around 2:30 a.m. PT.
The Integrated Homicide Investigation Team has been notified, police said, and will likely take over the investigation.
Police said weapons were involved in the assault, but released no further information.
More to come