The boy, whose name has not been released, was taken to hospital where he later died.
A second teenager also sustained minor injuries in the attack.
Police said the two boys were assaulted on 18th Avenue by a group of other teens at around 2:30 a.m. PT.
The Integrated Homicide Investigation Team has been notified, police said, and will likely take over the investigation.
Police said weapons were involved in the assault, but released no further information.
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