Police are warning motorists to avoid the area, as Bay Street is closed off starting at Queen Street West and Richmond Street West traffic is shut down with traffic being diverted to Yonge Street. Police say all directions at Bay and Richmond are closed.
The collision happened before 11 a.m. on Friday.
Toronto Paramedics are reporting one person has been sent to St. Michael's Hospital, though they are unsure of the patient's condition.
More to come.