Thirty-seven Canadian Armed Forces doctors, nurses, medics and support staff began working Tuesday at a British-run clinic in Kerry Town.
The centre has been set up primarily to provide care for local and international health-care workers who contract Ebola.
The command and support staff with the mission will be deployed for up to six months and the health-care staff will be rotated every two months.
The commander of Canadian Joint Operations Command, Lt.-Gen. John Vance, says their efforts will help alleviate human suffering and save lives.
Canada has also been operating a mobile laboratory in Sierra Leone since June; it is based at Kailahun in the eastern part of the country.
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