One man in critical condition was also rushed to hospital from the scene of the four-vehicle collision near Canyon Hot Springs.
Traffic was backed with the highway closed in both directions between Revelstoke and Golden, B.C. It is expected to reopen sometime between 8 p.m. and 12 a.m., according to DriveBC.
Revelstoke RCMP Cpl. Thomas Blakney said the crash involved three pick-up trucks, one of which was towing a trailer, and a car. He declined to comment if weather was a factor in the collision.