The crash yesterday afternoon closed the highway in both directions from Revelstoke to Golden for hours, backing traffic up for several kilometres.
Cpl. Thomas Blakney said three pickup trucks and a car were involved in the accident.
Road conditions were slippery at the time, but Blakney wouldn't speculate on whether that was a factor in the crash.
The names of victims have not yet been released, and police say their investigation is continuing.