The show's writer and mock-correspondent Abdul Butt called out to Cosby, who has lately been the subject of numerous allegations of sexual assault going back decades.
"Hey, Bill, congratulations on your first show in 2015!" Butt yelled. "Way to start the year off with a bang! Hope it was consensual this time, though, Billy."
There appeared to be no response from Cosby or his handlers.
Protesters gathered outside the Centre in the Square theatre before the show to protest Cosby's appearance.
He has two more Canadian dates:- Thursday night (tonight) in London, Ont.
- Friday night (tomorrow) in Hamilton.
ALSO ON HUFFPOST: