Following a standing ovation from a half-filled hall in Kitchener, Ont., and a confrontation with a heckler in London, Ont., protester Anne Bokma said Cosby shouldn't expect a warm welcome in Hamilton.
Protests are planned for both outside and inside Hamilton Place Theatre. The show's promoters have added additional security to head off disruptions of the show.
Cosby has not been charged and through his lawyer has denied all of the allegations against him.
CBC News will have reporters inside and outside the venue tonight. You can follow along with our live blog here:
In London on Thursday night, a heckler yelled out that the comedian was a rapist.
The man was removed from the theatre by a police officer while another member of the audience yelled to Cosby, "We love you." The comedian then continued with his routine.
A few minutes earlier, a woman who got up from one of the front rows and walked past the stage was asked by Cosby where she was going.
When she answered that she was going to the lobby to grab a drink, Cosby responded, "You have to be careful about drinking around me," which drew loud applause. Cosby has been accused by several women of drugging their drinks.
Cosby had expected hecklers at his Ontario shows, and issued a statement advising fans not to interact with protesters and to "stay calm."
Cosby issued a statement after the London show that read, "One outburst but over 2,600 loyal, patient and courageous fans enjoyed the most wonderful medicine that exists for humankind. Laughter. I thank you, the theatre staff [Budweiser Gardens], the event organizers and the ... community for your continued honour and support. I'm far from finished."