The fatal incident happened near Broadview Avenue and Riverdale Avenue around 3:30 a.m. A silver Nissan slammed into a hydro pole, killing the driver, police said.
No one else was in the car, police said.
Broadview Avenue between Withrow Avenue and Langley Avenue has been closed for investigation.
In a separate incident, a cyclist was hit by a car on Kingston Road near Warden Avenue before 4 a.m.
He was rushed to hospital with life-threatening injuries, paramedics said.
The intersection has been closed for investigation.