Bidders flew in to Biddeford from as far away as California for Wednesday's auction of 212 cards from among the 1,400-card collection.
Troy Thibodeau of Saco River Auction Co. says cards depicting Hall of Famers, including Cy Young and Ty Cobb, went for $4,000 to $5,000 apiece.
The cards range in age from 1909 to 1911 and feature colour lithographs on the front and a tobacco advertisement on the back. The collection belongs to a Portland family that has chosen to remain anonymous.
Thibodeau says because it is so big, the collection will be sold in installments over the year. The next group of cards will be auctioned in February.