The family-owned fashion retailer is slated to open a two-level, 88,000-square-foot location in Londonderry Mall in the fall of 2017.
Simons already has a store at West Edmonton Mall.
The 175-year-old company recently announced plans to launch in Vancouver, Calgary, Mississauga, Ont., Ottawa and Gatineau, Que.
John Simons originally founded the company as a dry goods store in Quebec City in 1840.
Simons has more than 2,000 employees and offers an extensive range of apparel from moderately priced separates to higher-end offerings made by a stable of homegrown and international designers.
Simons is set to launch at Les Promenades Gatineau in Quebec in August, followed in October by an opening at Park Royal in West Vancouver.
In 2016, Simons stores will open at Square One in Mississauga in March and Ottawa's Rideau Centre in August. Simons is slated to open at The Core in Calgary in March 2017.