Fred Horne, who served as health minister from October 2011 to last September, says he won't seek re-election.
Horne has represented Edmonton-Rutherford since 2008 and is currently a backbencher.
In a note to supporters Horne says he looks forward to supporting Premier Jim Prentice and the Progressive Conservative party in the future.
Horne's announcement comes a day after former finance minister Doug Horner announced that he will resign at the end of this month.
The announcements come amid growing speculation of a possible provincial election this year.
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