MacLeod, who pulled out of the Ontario PC leadership race two weeks ago, says she was re-elected to a four-year term last June and intends to stay at Queen's Park until 2018.
MacLeod issued a statement saying she received a lot of encouragement to run federally but decided with her husband that it was not a "realistic option" for their family.
She says they decided their nine-year-old daughter, Victoria, "deserves a break from door knocking, phone calls and late night campaign meetings."
MacLeod, who was first elected to the Ontario legislature in 2006 in the riding of Nepean-Carleton, threw her support behind deputy PC leader Christine Elliott when she withdrew from the leadership race.
Elliott, the widow of former finance minister Jim Flaherty, is being challenged by London-area MPP Monte McNaughton and Barrie MP Patrick Brown.
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