The team says Rose reported the knee pain on Tuesday, and an exam and MRI confirmed the injury.
Rose has been dogged by injuries for the past three seasons.
He tore the anterior cruciate ligament in his left knee in Game 1 of the 2012 playoffs against Philadelphia. The 2011 NBA MVP missed the entire next season, then played in only 10 games last season before a right knee injury shelved him for the rest of the season.
The Bulls say a timetable for his return will be determined after the surgery.