The St-Jacques overpass, between Girouard Avenue and Décarie Boulevard, will be closed in both directions from March 21 until Fall 2017.
The work had been originally scheduled to begin last July.
The closures will affect drivers using the St. Jacques exit of the the Ville-Marie expressway, as well as those travelling east along St-Jacques street.
Drivers will be forced to detour onto Décarie Boulevard, Upper-Lachine Road and Girouard Avenue.
The Transport ministry said workers will first move part of a sewage system located below the bridge, before starting to dismantle the St-Jacques overpass starting next year.
Until the demolition starts, local traffic will be allowed on St-Jacques Street between Addington Street and Décarie Boulevard.
Pedestrians will still be able to use all of St. Jacques St. until the end of 2015.
Transport ministry officials will hold a public information session to inform residents about the impact of the closure, on March 17, at 7:00 p.m. at the Saint-Raymond Centre, 5600 Upper-Lachine road in N.D.G.