Kraft bucked the trend, soaring 36 per cent Wednesday after reaching a deal to be acquired by Heinz.
The Standard & Poor's 500 fell dropped 30 points, or 1.5 per cent, to 2,076. The index is 2.6 per cent below the all-time high it reached March 2.
The Dow Jones industrial average lost 292 points, or 1.6 per cent, to 17,718. The Nasdaq slid 118 points, or 2.4 per cent, to 4,876.
Nine of the 10 industry sectors in the S&P 500 index fell. Energy was the only sector to rise, helped by a gain in the price of crude oil.
Bond prices fell. The yield on the 10-year Treasury rose to 1.93 per cent.