The collision occurred on Emmett Avenue, which is now closed between Verona Avenue and Eglinton Avenue West. Paramedics were called to the scene at 6 p.m.
There is no immediate word on the condition of the injured officers.
Police say the collision is under investigation.
Four people are now in custody, according to police.
The TTC says that buses on its 32D Eglinton West are currently diverting along Jane Street and Weston Road as a result of the police investigation.