Besides cocaine, heroin and 23,000 fentanyl pills, police say they have seized weapons including a crossbow, eight vehicles and $575,000 in cash.
Police say drugs are also believed to have been shipped to Vancouver Island and Alberta.
Supt. Mike Porteous says federal organized crime investigators and the RCMP assisted in serving search warrants in the city and in New Westminster, Coquitlam, Surrey and Maple Ridge.
The total value of the seizures is estimated at $1.8 million.
Police have already issued warnings about the painkiller fentanyl being mixed with heroin, oxycodone and other party drugs and causing several deaths among occasional drug users.