RCMP in Mackenzie say a small car collided with a pickup truck on Highway 97 at Bear Creek Bridge about 200 kilometres north of Prince George.
Police say two 18-year-old men believed to be from the Mackenzie area were pronounced dead at the scene.
The occupants of the pickup truck were taken to hospital with serious but non-life-threatening injuries.
The highway was closed briefly in both directions but re-opened later in the day.
A collision reconstruction expert is on scene to determine the cause of the crash.