The shutdown affects traffic in all four directions and drivers will face detours. It starts Monday and is scheduled to last until April 27.
Pedestrians will be able to access all sidewalks and businesses during the construction work.
The city is also shutting down the northbound lanes of Lower Sherbourne Street between Lake Shore Boulevard and Front Street for the next 10 weeks.
The shutdown is necessary so that crews can complete road repairs and "make modifications" to the intersection that connects Lower Sherbourne Street to the westbound Gardiner Expressway ramp.
All northbound traffic will be diverting along Parliament and Jarvis streets for the duration of the closure. A single southbound lane will remain open.
The Lower Sherbourne lane closures begin on Monday and are scheduled to last until June 15.