Bautista hit the last of Toronto's three home runs, and the Blue Jays beat the Baltimore Orioles 10-7 Sunday to complete a solid season-opening road trip.
After the Orioles cut a five-run deficit to 8-7, Bautista's two-run drive in the eighth off O'Day gave Toronto the cushion it needed.
The O'Day-Bautista confrontation has a history that includes tight pitches, strong language and home runs. This time, after O'Day threw a pitch behind the slugger, Bautista hit his first long ball of the year.
"Emotion of the moment. There's history there," Bautista said. "He's hit me a few times, he's thrown behind me a few times, and I've got him a few times."
It was his fourth home run in 15 career at-bats against the sidearmer, who's hit him twice.
"The smart play there was once I fell behind him, just try to pitch around him," O'Day said. "That's honestly what I was trying to do."
After the victory the Blue Jays headed north, hoping home-field advantage means more to them than it did to their opponents during the first week of the season.
Toronto won two of three from the Yankees in New York before duplicating the feat against the defending AL East champions at Camden Yards. Next up for the Blue Jays: Their home opener Monday night against Tampa Bay.
"It feels like we've been on the road forever," manager John Gibbons said. "It's been a long haul, so. So it'll be good to get back home."
Dalton Pompey and Kevin Pillar went deep for the Blue Jays, who doubled their home-run total for the season. Toronto scored 23 runs in the three-game series, twice reaching double figures.
Adam Jones and Travis Snider both homered and drove in three runs for Baltimore, and Manny Machado got his first hit to snap an 0-for-15 skid to start the season.
Orioles starter Chris Tillman (1-1) allowed seven runs, three earned, and six hits in 2 2-3 innings.
"They came out swinging," Tillman said. "I was never able to get any real command of any of my pitches."
Aaron Loup (1-1) pitched 1 2-3 perfect innings after starter Drew Hutchison gave up a career-high tying seven runs and seven hits in 4 1-3 innings.
Miguel Castro worked the ninth for his second save. After Pillar made an outstanding diving catch of a foul ball to left, Chris Davis hit a routine fly to Pillar with two runners on to end it.
Pompey put Toronto up 2-0 in the first inning with a drive to the top of the right-field scoreboard that wasn't called a home run until after a replay review of more than two minutes.
Jones countered in the bottom half with a two-run shot to centre, but the Blue Jays took the lead for good when Pillar homered leading off the second.
Toronto made it 7-2 in the third. After Tillman walked the bases loaded, rookie Devon Travis hit a two-out liner to right that Snider broke in on before backtracking. The ball glanced off his glove for an error, allowing three runs to score, and Jose Reyes greeted reliever Kevin Gausman with an RBI single.
Davis and Jones delivered RBI singles in the Orioles' half.
Snider hit his first home run with Baltimore, a three-run drive in the fifth that made it 8-7 and chased Hutchison.
Blue Jays: Bautista's homer was his 204th with Toronto, moving him past Joe Carter into sole possession of third place on the team's career list.
Orioles: Jones' home run was his 91st at Camden Yards, tied with Brady Anderson on the career list behind Rafael Palmeiro (124).
Blue Jays: OF Michael Saunders (left knee surgery) played five innings in the outfield with Class A Dunedin Saturday and was expected to DH Sunday. Toronto GM Alex Anthopoulos said Saunders could possibly return during the homestand.
Orioles: 2B Jonathan Schoop was scratched with a sore left quadriceps and replaced by Ryan Flaherty.
Blue Jays: Toronto sends R.A. Dickey (1.42 ERA) to the mound against Tampa Bay in the opener of a four-game series.
Orioles: LHP Wei-Yin Chen starts for Baltimore against the visiting Yankees and RHP Michael Pineda to start a three-game series.Suggest a correction