During his Sunday night headline set at the Coachella Valley Music and Arts Festival in Indio, Calif., Drake, 28, invited Madonna, 56, to join him. At the end of her short set, Madonna planted a lengthy, open-mouth kiss on the Toronto native.
"What the f--- just happened?" Drake said as Madonna walked off the stage.
Madonna is no stranger to kissing younger music stars. During the 2003 MTV awards show, she famously kissed both Britney Spears and Christina Aguilera.
People are Twitter are reading a lot into Drake's reaction to the kiss.
Some are posting about their own reaction.
But if you're grossed out by Madonna kissing Drake, check your own prejudices.