Health Minister Rona Ambrose says Ottawa plans to spend $13.5 million over the next five years for on-reserve support programs.
Ambrose made the announcement before touring the All Nations Healing Hospital in Fort Qu'Appelle, Sask., near Regina.
Ambrose said prescription drug abuse is a significant health and safety concern in North America.
Saskatchewan First Nations and partners are to receive more than $2.6 million of the funding.
Part of the money is to go toward a crisis intervention team to be co-ordinated through two regional hubs — one in Saskatchewan and one in Manitoba.