Highway 400 has the following closures:
- Northbound: Highway 88 to Mapleview Drive.
The crash happened north of Highway 89 near Innisfil at about 2:15 a.m.
Sgt Kerry Schmidt told CP24 the northbound truck lost control on the slippery surface and "punched through" the centre wall and struck the southbound Mustang. He said the woman in the car was pronounced dead at the scene.
Her name and age have not yet been released.
The driver of the truck suffered minor injuries.
Schmidt said a "bunch of cement has been pushed out into the southbound lanes" and it will take most of the morning to clean up.
He said other transport trucks were involved in similar collisions just north of the accident scene due to slick road conditions..
4 tractor-trailer crashes close Highway 401 west of Guelph Line
There are reports of four separate crashes involving jackknifed tractor-trailers in the area of Highway 401 near Highway 6 south of Guelph.
One jackknifed tractor-trailer has led to the closure of all westbound lanes of Highway 401 at Guelph Line, with reports of icy conditions in the area.