The agency is estimating around 8,000 turkeys will be euthanized on the farm.
The virus was first detected on an Oxford County farm in early April with 44,800 turkeys affected. More than a week later a second Oxford County farm tested positive with 27,000 broiler breeder chickens infected.
Avian influenza is an infectious viral disease of birds. Most bird flu viruses do not infect humans or pose a food safety risk when poultry products are properly handled and cooked.
The CFIA has set up two avian influenza control zones, which each span a 10-kilometre radius. One is located in Oxford County and the other covers portions of Oxford County and Waterloo County.
All poultry farms within those zones are under quarantine, meaning no poultry within those areas can leave the premises.