Police say they started the month-long investigation into the shop following a number of "events involving young people."
In Wednesday's raid, police say they entered the store, searched it for additional evidence and arrested staff who were later released. The store's customers were also identified during the raid, but then released pending investigation.
"Our priority remains focusing on violent drug traffickers and those who prey on youth and the marginalized in our community," the police said in a statement.
"However, these shops are all illegal and the VPD will continue to respond to concerns and take incremental steps to decide if further investigation or enforcement action is required."
Pot dispensaries facing regulation
The raid comes at the same time the city announced it wants to bring in regulation over Vancouver's more than 80 pot dispensaries.
CBC reported on Tuesday that marijuana operators are well aware their prior police involvement could come back to haunt them as they face background checks.
Police say they have obtained nine search warrants for medical marijuana dispensaries in the past 18 months.
Last year Vancouver police raided Jim's Weeds Lounge, a medical marijuana shop, saying they had received reports marijuana was being bought at the store and sold to youth in the surrounding neighbourhood.
"Police will take action again if there are public safety concerns, particularly if they involve youth," the statement said.