Two vehicles — a car and a sports utility vehicle — were travelling in opposite directions along SW Marine Drive, when one driver tried to make a left turn onto Manitoba Street.
The crash destroyed both vehicles, and sent the car spinning off the road.
The driver of the car suffered a head injury, according to officials, but he was conscious and breathing.
After using the jaws of life to remove the man from his car, Vancouver firefighters loaded him onto a stretcher and into an ambulance.
An eastbound section of SW Marine Drive was closed for several hours while Vancouver Police investigated the accident.