Here's a guide to help you chew through some 14-plus hours of virtually uninterrupted action:
10 a.m. ET: Liverpool vs. Queens Park Rangers
Liverpool doesn't have much to play for, sitting 22 points behind Premier League-leading Chelsea with only four matches to play, but the stakes are high for QPR as it fights to avoid relegation.
12:30 p.m. ET: Capitals vs. Rangers
Start your afternoon with a star-studded NHL playoff game at the World's Most Famous Arena. Alex Ovechkin scored a goal and assisted on the last-second winner as the Caps took Game 1 at Madison Square Garden. Henrik Lundqvist and the Rangers look to pull even in the second-round series.
1:35 p.m. ET: Yankees vs. Red Sox
Baseball's most storied rivalry continues at landmark Fenway Park in the second of a three-game weekend set.
3 p.m. ET: WGC Match Play
It's not a major, but an elite field of golfers including Masters champ Jordan Spieth and world No. 1 Rory McIlroy playing in a unique one-on-one format will at least give you something to flip to during commercial breaks.
4:10 p.m. ET: Blue Jays vs. Indians
Toronto's young flamethrower Aaron Sanchez takes the mound against Cy Young winner Corey Kluber.
6:24 p.m. ET: Kentucky Derby
The 141st running of horse racing's most prestigious event boasts a deep field of contenders. The favourite is American Pharoah (yes, that's how they spell it), who some think has a shot at becoming the first Triple Crown winner since Affirmed in 1978.
8 p.m. ET: Spurs vs. Clippers
It's Game 7 of a first-round series that features the skill and intensity of an NBA Finals. The defending champion Spurs remain superb, but they're aging, and a loss here could trigger the end of their long run of excellence.
11 p.m. ET (approx.): Floyd Mayweather vs. Manny Pacquiao
The main event. The two best fighters of their generation will finally meet in the ring at the MGM Grand in Las Vegas for a 12-round welterweight bout that is the richest in boxing history. The defensively impenetrable Mayweather is a 2-to-1 favourite to defeat Pacquaio, a dynamic puncher.Suggest a correction