The Royal Newfoundland Constabulary says it is working with the provincial Autism Society to create the voluntary registry.
Police say it will give them quick access to information about a registered person with autism, including contacts, physical descriptions, known routines or their special needs.
Scott Crocker of the Autism Society of Newfoundland and Labrador says it can help officers talk to people with autism or those dealing with them in an emergency.
The program is being launched and implemented in St. John's.
Police and first responders in other Canadian cities have similar programs in place.