The collaboration kicked off last month when Gonzo, Rizzo and Kermit doppelgänger Constantine popped up in a detective-themed video on YouTube's VSauce3 channel.
Other upcoming appearances will include Dr. Bunsen Honeydew and Beaker answering science-related questions on the Mental Floss channel and the whole Muppet gang performing "Pure Imagination" with violinist Stirling on her channel.
The videos were filmed on location at YouTube Space LA, a new studio operated by the streaming service in West Los Angeles.
YouTube is celebrating its 10th anniversary throughout the month of May. It opened with its public beta launch in May 2005.