The collision leaves Highway 20 eastbound closed during rush hour for an expected two to three hours while police are on the scene — peak morning hours for anyone trying to commute into the city.
One vehicle was driving in the wrong direction on the highway when it hit another vehicle.
The person driving in the wrong direction is a man in his 70s. He is expected to survive.
The other vehicle caught on fire shortly after the impact, and its driver is in critical condition.
There was only one person in each vehicle.
Police and firefighters are on the scene.