Providence Health Care announced last month that St. Paul's Hospital will close its West End location and move to a new location in East Vancouver, near Main Street and Terminal Avenue.
"It means we will see a lot more ambulance traffic, a lot more police traffic that goes with that sometimes, a lot more citizen traffic," said one resident Josh Young at a community meeting on Wednesday evening.
However, the hospital redevelopment chief project officer Neil MacConnell said that the new location will mean better access for city residents.
"That's a very central location from a transportation perspective. Even people coming from outside the city can get to that location," he said.
He added that new facility will be built with the potential to expand.
"It's a site that's vacant at this time, so lots of capacity and more capacity to build our hospital."
Providence Health Care still has to produce a business case and concept drawings for the government to approve.
Elana Zysblat of the Strathcona Residents' Association says her group will be closely watching the development plans.
"I think there's a great opportunity we might be lucky to have a great site like this going up near us, but we also have to watch the process very, very carefully to make sure we're avoiding any negative impacts," she said.