Fire officials said up to 10,000 litres may have spilled at Pounder Emulsions, a division of Husky Oil Ltd.
Three people were treated for inhalation of fumes but were not taken to hospital. Some nearby businesses were also evacuated.
“A tanker truck had delivered the material to this business and when they were offloading the material, a spill occurred," said Morgan Hackl, assistant chief of the Saskatoon Fire Department.
Hydrochloric acid is clear, colourless, and has a pungent smell.
It is a highly corrosive, strong mineral acid with many industrial uses.
Hackl said crews will use dry sand to cover the acid and a private company will then remove the contaminated material.
John Miller, a spokesman for Husky Energy, said the company is already investigating to determine what happened.
"Of utmost priority is the safety and protection of the public and all responders," Miller said. (CKOM)