Sgt. Claude Denis of the Sûreté du Québec said the crash happened around 1:30 a.m. Sunday on Highway 440 near the 24-kilometre mark.
A vehicle travelling in the wrong direction crashed into another car. A third vehicle had its driver's-side door ripped off by the impact.
The driver of that vehicle received minor injuries and has been discharged from hospital.
Police arrested the drivers of the other two vehicles, both for impaired driving.
Eastbound Highway 440 is closed. A detour via Industriel Boulevard South and St-Martin Boulevard East has been set up.