Saquanna Dante Duncan was last seen yesterday evening at 5:30 p.m. in the Keele Street and Threthewey Drive area in the Eglinton West neighbourhood.
Police have established a command post on Keele Street, near the intersection where Duncan was last spotted, to help in the search effort.
Duncan is described as five-feet, five-inches tall, about 80 pounds, with brown hair that was in a ponytail. She was wearing a grey sweater, white polo shirt, blue track pants and white shoes with a red stripe. She was also carrying a burgundy and white backpack.
Anyone with potentially helpful information is asked to contact police at 416-808-2222 or to contact Crime Stoppers by phone or online.