It will be the co-feature on a card featuring Sergey (Krusher) Kovalev (27-0-1), who holds three light heavyweight belts, against mandatory challenger Nadjib Mohammedi (37-3).
Pascal's last bout was an eighth-round loss to Kovalev on March 14 in Montreal. Pascal (29-3-1) will be in his third fight in a seven-month span, including a two-round no-contest against Roberto Bolonti in December.
"I'm eager to get back in the ring," Pascal said in a statement. "The years where I have been very active are the ones that I've performed the best.
"Gonzalez is a good fighter and everybody knows I am not content with fighting just a regular fighter."
Pascal, 32, lost the WBC title to Bernard Hopkins in 2011.
The 29-year-old Gonzalez (16-0) has stopped his last seven opponents before the limit.
"This is the fight I have been waiting for," said Miami-based Gonzalez. "I'm not punching at him, I'm punching through him. And when I'm done with him he won't be any good for anyone else."
The bouts are co-promoted by Pascal, InterBox and Main Events and will be shown on the HBO specialty channel.