The TO2015 torch relay, which will continue until the Games begin on July 10, will visit many communities across Ontario as well as major Canadian cities including Halifax, Montreal, Winnipeg, Calgary and Vancouver.
Saturday's route begins at Harbourfront Centre at 2:30 p.m. and runs east along Queen's Quay, up Yonge Street and across Front Street to the Distillery.
Chris Hadfield will be among the torchbearers carrying the flame through Toronto. He's set to run the torch into the Distillery District around 4 p.m.
In total, some 3,000 people will carry the torch during the relay, which will cover more than 5,000 kilometres on the ground and some 15,000 kilometres in the air.
And if you're not a torchbearer, but still want to see the Games' flame, the Distillery District event is open to the public from 1 to 6 p.m.
The relay will be back in Toronto on July 5 to cover more of the city in the leadup to the Games.
Saturday also marks the torch's arrival on Canadian soil, after it was lit in Mexico, where the last Games took place.