"Om the Bridge" will block the major thoroughfare through the city for seven hours on June 21.
The province and other supporters, including local companies and the cities of Surrey and Vancouver, are hoping the event will be the largest International Day of Yoga celebration outside of India.
Premier Christy Clark says in a news release that yoga is a great gift from India to the world and the discipline has become part of the Vancouver area's cultural fabric.
Clark has focused on building stronger ties with India and recently visited the country on trade missions and personal vacations.
Indian Prime Minister Narendra Modi promoted International Day of Yoga when he visited B.C. in April.