The film brought in a whopping $208.8 million in its first weekend in theatres, according to Universal Pictures on Monday.
It's the highest-grossing opening weekend of all time.
Chris Pratt stars in the fourth installment of the popular series, directed by Colin Trevorrow.
Internationally, the film grossed a similarly mighty $315.3 million, bringing its international total to a record $524.1 million.
"Marvel's The Avengers" had previously held the domestic all-time opening weekend record. That film opened to $207.4 million in 2012.
"Jurassic World" is the latest in a string of successes for Universal in 2015, including "Fifty Shades of Grey," ''Furious 7" and "Pitch Perfect 2."