It comes after months of work by the Montreal Urban Aboriginal Community Strategy Network.
"There's very few other cities who have done this, and those that have done it were put together by the police" said Nakuset, the co-chair of the network and the executive director of the Native Women's Shelter of Montreal.
"This is the first time where the Montreal urban aboriginal community has met with the police, created something, and they're accepting it."
The agreement will establish new training for police officers and teach them about aboriginal culture and history.
It will also create a protocol to improve prevention and response to cases of missing and murdered indigenous women.
"Communities have been asking to create protocols for missing and murdered aboriginal women for the longest time and no one's done anything," said Nakuset.
She added that the protocol established under this agreement could be used as a blueprint for other cities.
Nakuset says the signing of the agreement should take place Thursday afternoon. Montreal police could not be reached for comment.
Nakuset will give more details about the agreement on Daybreak at 7:15 a.m. Listen online here.