Police were called early Friday to a report of a serious vehicle rollover on the highway east of Tete Jaune Junction, about 40 kilometres west of the Alberta boundary.
Officers say when they arrived at the crash site they found a 28-year-old man and 29-year-old woman both dead.
The highway was closed for seven hours while police investigated the scene.
Police say excessive speed is believed to be a major factor, although the cause of the crash is still under investigation.
Both victims are from British Columbia.