The crash happened shortly after midnight at the intersection of Kipling Avenue and Jutland Road, just north of the Gardiner Expressway.
It appears the SUV was southbound and turning left onto Jutland when the motorcycle slammed into the passenger side.
The motorcyclist was pronounced dead at the scene.
The two people in the SUV were taken to hospital with non-life-threatening injuries.
Kipling Avenue was closed in the area overnight, but has since reopened.