Officers say 24-year-old Mohamed Ibrahim Sail is wanted on a second-degree murder charge in the death of 18-year-old Jeremy Cook.
London police say his current whereabouts are unknown and he is considered dangerous.
Police say Cook was killed June 14 after tracking his cellphone to a car with three men inside and was shot multiple times when he grabbed the car as it began to drive away.
Another Calgary man, 23-year-old Muhab Sultan, was also wanted for murder but was found dead in the Rideau River on June 27 after police say he ran away from officers and fell under.
Investigators say a third suspect has been identified but is not co-operating.
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